Please use this identifier to cite or link to this item: http://dspace.aiub.edu:8080/jspui/handle/123456789/2416
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAra, H.-
dc.contributor.authorTarek, S. A.-
dc.contributor.authorBiswas, M. K.-
dc.contributor.authorDin, S. M. S. Al-
dc.contributor.authorHoque, E.-
dc.contributor.authorHasan, K. M. E-
dc.contributor.authorHossain, A. K. M. M.-
dc.contributor.authorFaruque, S. B.-
dc.contributor.authorHaque, Y.-
dc.contributor.authorSharafuddin, S. M.-
dc.date.accessioned2024-09-22T08:36:28Z-
dc.date.available2024-09-22T08:36:28Z-
dc.date.issued2004-05-22-
dc.identifier.issn2057-1976-
dc.identifier.urihttp://dspace.aiub.edu:8080/jspui/handle/123456789/2416-
dc.description.abstractThe Z-scan technique is a nonlinear optical method that has found applications in characterizing various materials, particularly those exhibiting nonlinear optical response (NLOR). This study applies the continuous wave (CW) Z-scan technique to examine the NLOR in terms of the nonlinear optical phase shifts (ΔΦ_0) exhibited by the ccfDNA extracted from blood plasma samples collected from a group constituting 30 cancer-diagnosed patients and another group constituting 30 non-diagnosed individuals. The cancer group exhibited significantly higher ΔΦ_0vs. incident power slopes compared to the non-cancer group (0.34 vs 0.12) providing a clear distinction between the two groups. The receiver operating characteristic (ROC) curve analysis of the results indicates a clear separation between cancer and non-cancer groups, along with a 94% accuracy rate of the data. The Z-scan results are corroborated by spectrophotometric analysis, revealing a consistent trend in the concentration values of ccfDNA samples extracted from both cancerous and non-cancerous samples, measuring 3.24 and 1.41 respectively. Additionally, more sensitive fluorometric analyses of the respective samples demonstrate significantly higher concentrations of ccfDNA in the cancer group, further affirming the correlation with the Z-scan results. The study suggests that the Z-scan technique holds promise as an effective method for cancer detection, potentially contributing to improved oncology diagnosis and prognosis in the future.en_US
dc.language.isoenen_US
dc.publisherInstitute of Physicsen_US
dc.subjectCirculating cell-free DNAen_US
dc.subjectNonlinear optical responseen_US
dc.subjectCW Z-scanen_US
dc.titleInvestigating the Z-scan technique for quantifying circulating cell-free DNA (ccfDNA) extracted from blood plasma as a potential biomarker for various cancersen_US
dc.typeArticleen_US
Appears in Collections:Publication: Journal

Files in This Item:
File Description SizeFormat 
BPEX_IOP2024_Page-1.pdffirst page389.47 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.