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Title: A one pot synthesis of 7,11-diaryl-2,4-diazaspiro[5,5]undecane-3-oxo(or thioxo)-1,5,9-triones
Authors: Ahmed, M. Giasuddin
Ahmed, S. Asghari
Romman, U. K. R.
Akhter, Kawsari
Halim, Md. Ershad
Naher, Shamsun
Aslam, M.
Ahmed, S. Mosaddeq
Keywords: Spiro compounds, diarylideneacetones, barbituric acid, 2-thiobarbituric acid, Michael addition
Issue Date: Jul-2011
Publisher: Bangladesh Chemical Society (BCS)
Series/Report no.: 24(2);Page 135-142
Abstract: Spiro compounds 7,11-diaryl-2,4-diazaspiro[5,5]undecane-1,3,5,9-tetraones 3a-d were prepared by carrying out reactions between diarylideneacetones, (ArCH=CH)2C=O, 2a-d [Ar= 2-CH3C6H4, 4-CH3C6H4, 4-(CH3)2NC6H4 and 4-HOC6H4 respectively] and barbituric acid (1a) under refluxing condition in aqueous ethanol medium without using any catalyst. Under similar conditions the corresponding 7,11-diaryl-3-thioxo-2,4-diazaspiro[5,5]undecane-1,5,9-triones 3e-g were synthesized from the reactions of diarylideneacetones 2a, 2d and 2e [Ar= 4-ClC6H4] with 2-thiobarbituric acid (1b). The structures of the spiro compounds were established with the help of their UV, IR, 1H NMR, 13C NMR and mass spectral data and elemental analyses.
ISSN: 1022-016X
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